Detailed Review Desmopressin nasal spray Usage, Side effects

Written by tanaypatel5212

June 14, 2021

 Desmopressin Nasal Spray Full Review

Today we will discuss desmopressin nasal spray in detail. Before we start our blog we notify you that this blog is just for informative purposes, We do not provide any medical prescription and diagnosis.

What is Desmopressin Nasal spray used for?

The excretory system plays a major role in maintaining body balance by removing unwanted substances from the body. Urinating is also part of the excretory system, which helps maintain water balance in the body and electrolytes balance.

Image credit:- Freepik

Medical conditions like Diabetes insipidus, Brain trauma, Trauma to the central nervous system can cause excessive urination. This can lead to dehydration and low water content in the body.

So to prevent excessive water loss through the urinary system desmopressin nasal spray is used.

How Does Desmopressine Nasal Spray work?

Desmopressin Spray contains the active ingredient desmopressin, which is the type of medicine called vasopressin analog. It is similar to the hormone produced by the body called antidiuretic hormone or vasopressin.

ADH or Anti Diuretic Hormone is produced by the pituitary gland, It is involved in the controlling natural balance of water levels in the body. It normally acts on the receptors in the kidneys to prevents excessive amounts of water, being filtered out of the blood and into the urine.

Desmopressin is similar in structure to this hormone and works by mimicking its action.

Video Courtesy: Telehealth Pharmacy(YouTube)

In the conditions like diabetes insipidus, the kidney produces excessive amounts or quantities of very dilute urine but otherwise normal urine. This causes excessive thirst and leads to dehydration.

Diabetes insipidus can be caused by a problem with the kidney itself or by a deficiency in the production of ADH or antidiuretic hormone. Desmopressin works by binding to the ADH receptors in the kidneys, which mimics the effects of natural ADH, this reduces the production of urine.

Desmopressin can also be used to prevent excessive urination at night or nocturia in people with multiple sclerosis. It is useful when another treatment is unsuccessful.

What is Desmopressin Nasal spray?

Desmopressin spray is a nasal spray that is administered in the turtles, desmopressin is absorbed into the bloodstream from the direct supply of blood vessels lining the nasal passages, So you follow the instructions for use that are provided with the leaflet.

This product is to be used with caution in elderly people, people with decreased kidney functions and disease involving the heart and blood vessels, cystic fibrosis, and an imbalance of water and salt concentration in the blood.

It is not used in people with the syndrome of inappropriate ADH secretion, a low level of sodium in the blood, and a history of heart failure. This medicine should not be used if you are allergic to one or any of its ingredients.

Also, tell your doctor or pharmacist if you have any previous history of analogy and with this product. If you experience any analogy or allergy with this product stop using it immediately and contact your doctor.

Indication For Desmopressin.

Central Cranial Diabetes Insipidus: DDAVP Nasal Spray (desmopressin acetate nasal spray) is indicated as antidiuretic replacement therapy in the managing of fundamental cranial diabetes insipidus as well as also for the management of the temporary polyuria and polydipsia following head trauma or surgery in the adrenal area.

Using DDAVP Nasal Spray (desmopressin acetate nasal spray) in patients with a proven diagnosis will end in a decrease in urinary output with growth in urine osmolality along with also a drop in plasma osmolality.  This can allow the resumption of a more normal lifestyle with a decrease in urinary frequency and nocturia.

Patients are chosen for remedy by establishing the identification with the water deprivation test, the hypertonic saline infusion test, or the answer to antidiuretic hormone.  Continued response to intranasal DDAVP is tracked by urine volume and osmolality.

DDAVP is also offered as a solution for regeneration whenever the intranasal course could possibly be jeopardized.  These situations include nasal congestion and blockage, nasal discharge, atrophy of nasal mucosa, and acute atrophic rhinitis.  Intranasal delivery could also be improper where there is definitely an impaired level of consciousness.  In addition, cranial surgical procedures, such as for example transsphenoidal hypophysectomy cause situations where an alternate path of management will become necessary as in cases of nasal packing or recovery in surgery.

Additionally, there are reports of an occasional shift in reaction with time, commonly greater than 6 weeks.  Some patients may demonstrate a low responsiveness others a shortened amount of result.  That isn’t any evidence that this effect is due to this development of binding antibodies but can be caused by a neighborhood inactivation of this peptide.

ContraIndication for Desmopressin Nasal Spray

Desmopressin nasal spray is contraindicated in patients with moderate to severe renal impairment (defined as a creatinine clearance below 50ml/min).

Desmopressin nasal spray is contraindicated in patients with hyponatremia or even a brief history of hyponatremia, hypersensitivity to desmopressin acetate, or any component of spray.

Side effects of desmopressin nasal spray

Your doctor or consultant physician only prescribes you for your health benefit and so many people do not get any side effects. But in some rare cases, of allergy or hereditary condition patient might develop some side effects includes;

  • Headache
  • Stuffy nose/Runny nose
  • Nausea
  • Flushing of face
  • Stomach upset

If any of the above effects get worse or become more prominent immediately context your doctor or consultant, Also read the warning section before using the spray.

A very serious allergic reaction to this drug is rare.  However, seek medical help right away if you notice any signs of a severe allergic reaction, including

  • rash,
  • itching/swelling (particularly of the face/tongue/throat),
  • severe dizziness,
  • trouble in breathing.

This isn’t a comprehensive list of possible side effects.  If you notice other effects not listed above, contact your doctor or pharmacist.

Precaution For Desmopressin Nasal Spray

This product may contain inactive ingredients, which may lead to allergic reactions or other problems.  Speak to your pharmacist for additional information.

Before using this medicine, tell your doctor or pharmacist your medical history, especially of: liver disease, heart problems (such as obstructed blood vessels, heart failure), higher blood pressure, conditions that may increase your chance of fluid/mineral imbalance (such as cystic fibrosis), the impulse to drink too much water without being hungry, a low amount of sodium in the blood (hyponatremia), bleeding/clotting issues.

If you become dehydrated, your doctor will correct that condition first before beginning treatment with desmopressin.

Limit alcohol because it can interfere with how well desmopressin works.

Changes within the nose (such as swelling, discoloration, congestion, or blockage) may influence how well desmopressin nasal spray has been consumed.  Tell your physician if you have any of these changes within the nose because they might want to modify your therapy.

Tell the physician at once in case you create any ailment which may lead to water/mineral imbalance (such as fever, nausea, nausea, diseases like the flu) or if you undergo problems that require drinking fluids (as an example, exposure to scorching weather, even strenuous exercise, even long-term perspiration ).  The physician may have to discontinue or adjust desmopressin therapy, especially in young children and older adults.

Children might be more vulnerable to the side effects of this drug, especially water/mineral imbalance and a low amount of sodium in the blood vessels.

Kidney function declines as you get older.  This medication is eliminated from the kidneys.  So, elderly adults may be at greater risk for water/mineral imbalance and a low level of sodium from blood whilst using this particular drug.

During pregnancy, this medication needs to be utilized only if obviously necessary. Explore the hazards and benefits with your doctor.

This drug passes into breastmilk. Consult Your Physician Before Breast Feeding.


So here we have discussed Desmopressin nasal spray we will update this article as we get some new information about it. If you have any doubt regarding any medical conditions you can tell us in the comments section awe will try to solve your doubt and queries.

Also, read our other health-related blogs for more information and awareness about health and mental health conditions.

Stay tuned with us for amazing informative content and health daily health-related blogs.

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